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Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment

Under normal conditions, glutathione levels are tightly regulated to ensure both adequate antioxidant capacity and controlled metabolic flux through its biosynthetic pathway

VSMC proliferation and intimal thickening also predispose individuals to oscillatory or low blood flow, which have been shown to induce leukocyte adhesion, enhanced vascular permeability, LDL oxidation, and atherosclerotic plaque formation 42,43,44

doi: 10.1016/j.pharmthera.2007.09.008, 109

4m) self-assembled from a PROTAC, a singlet oxygen-cleavable linker, and an NIR photosensitiser

The amount of iNOS and COX2 were normalized with respective -actin level and expressed as % non-LPS control (middle panel)