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Glutamine anaplerosis supplies glutamate, while the transsulfuration pathway provides cysteinethe rate-limiting precursor for GSH biosynthesis [57, 97]

Cases were stratified by CSs to study association with overall (OS) and disease-free (DFS) survival distinctions via Kaplan-Meier analyses and gene expression distinctions via Pearsons correlation

KD appears well positioned to intervene in this process, overlapping with broader microbiota-targeted strategiesincluding probiotics, synbiotics, FMT, and antibioticsthat are increasingly regarded as potential disease-modifying interventions in PD [129, 177]

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These pathways are coordinated by S-adenosylmethionine (SAM), which have a specific role as an allosteric inhibitor for the methylenetetrahydrofolate reductase (MTHFR) reaction and acts as an activator of cystathionine -synthase (CBS) [2]