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Cells were permeabilized using digitonin (1 g per 10 6 platelets or 6 g per 10 6 PBMCs), and simultaneously, the N-pathway substrates (or CI substrates) malate and pyruvate were added at saturating concentrations (5 mM each)

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It is pertinent to note, however, that mice and rats are not suitable models for humans in many significant areas, for example, in brain function, and reproduction, where human biology is remarkably different from that of rodents [47]

B12 is essential in converting food into glucose, the fuel our bodies run on

A review of neurobiological mechanisms in nerve degeneration and regeneration, including nerve compression and more severe nerve injuries, in healthy people and people with diabetes

-lipoic acid treatment (600 mg/day) has also demonstrated to improve neuropathic symptoms (pain, burning, paresthesia, and numbness) and deficits in patients with NP (Tesfaye, 2011)