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Clinical Endocrinology

[] In metabolic syndromes such as diabetes, insulin resistance, and obesity, the expression and function of PGC-1 are altered, affecting cardiac mitochondrial biogenesis and function

This may be because of the slow motility (constipation) causing the gas to become trapped in the GI tract for longer compared to the more diarrhea-dominant form of SIBO

In the epidermis of vitiligo lesions, a marked decrease in the expression of c-kit, the stem cell factor receptor, and the MITF transcription factor (microphthalmia-associated transcription factor) has been detected, along with a reduction in endothelin B receptor.40 A marked reduction in microRNA-211 expression has also been observed, associated with a lower oxygen consumption rate, aberrant mitochondrial complexes, alterations in lipid metabolism, and an increase in reactive oxygen species

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These CD36-mediated effects are independent of GHS-R1a and contribute substantially to GHRP-2s cardioprotective and cytoprotective activity in pre-clinical models