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When B12 is low enough to impair those two key enzymes, mitochondrial energy production slows, red blood cell formation becomes less efficient (which means less oxygen delivery to muscles and organs), and fatigue accumulates

Additionally, pyridoxine (B6), folate (B9), and cobalamin (B12) are indispensable coenzymes for the methylation of homocysteine to methionine, a process critical to nervous system function

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