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Cancer Cell 5 , 221230 (2004)

Signs of low vitamin B12 include: Fatigue Nausea Throwing up Diarrhea Losing weight without trying A sore tongue A yellow tinge to your skin Fuzzy thinking Numbness or tingling in your hands and feet Vision changes Trouble walking or speaking Feeling easily irritated Confusion Depression Many conditions share these same symptoms

doi:10.1177/0300060518786918

Virulence 4 , 366 (2013)

21 Fletcher-SandersjA.ThelinE

Here, elevated NO production as a result of increased activation of NOXs, in particular NOX4 leads to the stabilisation of HIF-1 and thus promotion of endothelial cell (EC) survival, migration, differentiation, and therefore neovascularisation 64,106,107,108