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[52] While elders are more sensitive to GH, and thus more susceptible to the side effects of replacement with rhGH, stimulating production and secretion of endogenous GH with Sermorelin offers the advantage of a more physiological approach to increasing GH pulsatility while reducing risk for side effects

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As the next phase of this research, more sophisticated in vivo models, incorporating chronic injury paradigms, long-term follow-ups, and genetic or pharmacological modifications of inflammatory pathways, will be critical to substantiate the translational potential of this approach

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Elevates oxygen-consumption rates in Seahorse and high-resolution respirometry protocols, enabling precise measurement of electron-transport-chain efficiency