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However, a prolonged half-life of more than 4 h can occur in individuals that either consume an overdose of APAP or that exhibit a clinical history of hepatic injury or chronic liver disease ( As APAP hepatotoxicity is the most common cause of acute liver failure requiring liver transplantation, a better understanding of the molecular events contributing to APAP hepatotoxicity may provide novel opportunities for intervention

Depression has recently been included in a list of 12 modifiable risk factors of dementia, but other disorders like anxiety have also been implicated in its onset (123)

12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress

My laboratory uses CRISPR/Cas9 gene editing technologies, next generation sequencing, pluripotent stem cells and mouse modeling to achieve this goal

Student (2018-2022) Assistant Professor, Institute of Microbiology of the Chinese Academy of Sciences Assistant Instructor (2021-2022) Senior Scientist, Genentech Graduate Student (2017-2021) Senior Scientist, Computational Biologist, Amgen Data Scientist (2016-2018) UT Southwestern M.D