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Second, the microneedle delivery data are in vitro on excised human skin

Figure 1 Granuloma formation occurs in intrathoracic lymph nodes, lungs, skin, heart, and other organs upon contact with antigen-presenting cells (macrophages, dendritic cells, activated epithelial cells) by a triggering agent, followed by the development of unregulated autoimmune inflammation, additionally characterized by an imbalance between pro- and anti-inflammatory acquired immune cell subsets (T- and B lymphocytes) as well as regulatory T cells (79)

For instance, LPS is an endotoxin located in the outer membranes of numerous Gram-negative bacteria

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Ciriolo, Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology