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Clinical evidence from randomised trials of antioxidant supplementation Despite strong preclinical evidence linking oxidative stress and ROS to breast cancer initiation and progression, clinical translation of antioxidant supplementation has not demonstrated consistent therapeutic or preventive benefit

Excellent dietary sources include citrus fruits, berries (particularly strawberries), bell peppers, broccoli, Brussels sprouts, tomatoes, and leafy greens

Most data comes from: That said, Dihexa is being used off-label in clinical practices, and practitioners continue to monitor real-world outcomes in: Despite promising data, Dihexa has not yet completed the rigorous phases needed for FDA approval

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The figure shows robust expression of ZO-1 in epithelial enterocytes of small intestinal organoids (which is diminished under CARD9-inhibited conditions)