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Through these triple mechanisms of Nrf2-dependent redox regulation, protein interaction, and inflammatory signaling blockade, hydrogen achieves synergistic inhibition of the NF-B signaling pathway (Hu et al., 2022)

Furthermore, the concomitant use of other drugs with acetaminophen has also been reported as a risk factor for ALI [59]

Regulation of cell proliferation and apoptosis: Glutathione depletion is a signal for apoptosis (programmed cell death), while adequate levels support normal cell proliferation [2][5]

Additionally, GSTs contribute to oxidative stress management by conjugating and eliminating reactive aldehydes such as 4-hydroxynonenal (4HNE), a lipid peroxidation byproduct associated with apoptosis and neurodegenerative disorders

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