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Animal studies indicate dose-dependent effects, with toxic doses possibly affecting copper metabolism or interacting with embryonic development in hypersensitive models, warranting caution during pregnancy

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Compounds with similar level of safety characterization would normally be in phase 1 trials with intensive monitoring, not on consumer market

The February 2026 reclassification reversed this for approximately 14 of those 19 compounds

Still, it's best to follow the maximum dosage instructions recommended by your healthcare provider or the label on your vitamin B12 supplements