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HIF-induced angiogenesis Under hypoxia, the activity of FIN-1 and PHDs , acting as oxidase-related groups, is inhibited, thus leading to decreased HIF-1 hydroxylation and proteasome degradation

The sequences thus identified can be compared to identify consensus sequence(s) and consensus sequence kernals

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For this reason, GSH implementation should not be used in drug-induced toxicities different than platinum-related neurotoxicity, that at this moment represents its only clinical indication

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This can be easily explained by the fact that NAC is often used concurrently with pro-oxidant agents and can reduce oxidative stress, most probably by reacting directly with them in the cell culture medium, and even when a pretreatment is declared, in most cases NAC is not washed away before the oxidative insult