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Doxycycline (Dox) induced robust production of the respective MLKL mRNA detected by qRT-PCR and proteins indirectly detected via the mCherry fluorescence signal (Fig

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Although all of the test compounds showed dose-dependent reversible inhibition of CES1, mitragynine showed full competitive inhibition, whereas speciociliatine, paynantheine, and corynantheidine elicited mixed-type reversible inhibitory effects