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Transfusional iron overload and chelation therapy with deferoxamine and deferiprone (L1)

Keywords: mitragynine, 7-hydroxymitragynine, Mitragyna speciosa , mitragynine pseudoindoxyl, plasma stability, metabolism Mitragynine is the most abundant and pharmacologically well-characterized alkaloid ( 66% of total alkaloidal content) 1,2 contained in the psychoactive substance kratom ( Mitragyna speciosa Korth.)

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S-adenosylmethionine (SAMe) SAMe is an endogenous molecule formed from the amino acid L-methionine and ATP by the enzyme SAMe synthetase and initiates three metabolic pathways (Figure 1): 1

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Basic physicochemical properties of DNZ-NLPs The polydispersity index (PDI), particle size, and particle surface charge (zeta potential) of B-NLPs and DNZ-NLPs were determined through the dynamic light scattering (DLS) technique, utilizing the Zetasizer instrument (Malvern Instruments Ltd., Worcestershire, UK) at 25 C