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SOD1 mutants have a range of symptoms, including poor respiratory growth, hypersensitivity to exogenous oxidants (like paraquat or menadione), stationary phase instability, and defects in methionine and lysine biosynthesis (Funada et al., 2022)

Sci Rep 6:34751

References: 1 Brunton LL, Knollmann BC, Hilal-Dandan R

I anticipate any waivers encouraged by the administration to be focused on restricting eligibility, rather than expansion efforts

Holm SK, Johansen VBI, Clemmensen C

Survodutide takes part in treatment of liver disease, mainly Metabolic Dysfunction-Associated Steatohepatitis, while simultaneously advancing through Phase 3 trials for obesity