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Culture of Nucleus Pulposus Cells Nucleus pulposus cells were collected from the lumbar disc of 10 male Sprague-Dawley rats (3 months old)

We use these results as a starting point to identify GAPDH as a neutrophil-intrinsic NET-suppressor mechanism and to investigate the molecular mechanisms by which GAPDH inhibition regulates neutrophil function

Neuropharmacology 32 , 895900 (1993)

Several aspects of our study merit further investigation

Loss of mitochondria depletes the energy available for contraction

191193 FXR activation promotes the secretion of GLP-1 from intestinal endocrine cells, which enhances insulin release, improves insulin sensitivity, and promotes glucose metabolism