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Therefore, the effectiveness of the use of the transporter-mediated prodrug approach for the brain delivery of drugs with brain extracellular targets is questionable

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Although studies have shown that Nrf2 and Nrf2-activating chemicals have opposing effects on the NLRP3 inflammasome that are not dependent on Nrf2-mediated gene expression, both effects are independent of the transcriptional activity of Nrf2 [129]