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Concurrent use of both cannabis and tobacco was associated with increased risk (even adjusted for age, asthma, and comorbidities) of respiratory symptoms (OR 2.39, 95% CI 1.583.62) and COPD (OR 2.90, 95% CI 1.535.51) if the lifetime dose of marijuana exceeded 50 marijuana cigarettes

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Statistical analyses were performed using REGENIE software to account for sample-relatedness and population structure, thereby increasing the robustness of genetic association results