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10.26355/eurrev_202211_30395 78

Cytotoxic effects of metformin and H 2 O 2 on chondrocytes were assessed using Cell Counting Kit-8 (CCK-8) based on the manufacturers instruction

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Restricted by suboptimal efficacy of a single target and limited target screening [302], the perspective should gradually shift from the doctrine of one molecule, one target, one disease to all-in-one NMs based on a multipronged strategy that synergistically modulates multiple metabolic targets in macrophages [175]