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Adv Mater (2020) 32:e2002054

10.1007/s12032-018-1229-x 183

& Jousilahti, P

Busulfan is an anticancer drug that kills undeveloped germ cells, affects spermatozoal production, and induces male infertility, and the drug has been used to establish a model of oligospermia

Moreover, they found that the expression of G6Pc and PEPCK, gluconeogenesis-related proteins, along with FAS and SREBP-1c, lipid metabolism-related proteins, were repressed in these cells, while the expression of PPAR, another lipid metabolism-related protein, was notably downregulated