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On the pharmacology side, HGF-induced MET activation exerts beneficial neuroprotective effects also in adulthood, specifically in neurodegenerative disease, and in preclinical models of cerebral ischemia, spinal cord injuries, and neurological pathologies, such as Alzheimers disease (AD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS)

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End stage renal disease (ESRD) with loss of kidney function results in renal replacement therapy with the need for dialysis or renal transplantation [29]

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However some people may have symptoms of vitamin B12 deficiency despite normal vitamin B12 blood test results, or may have low blood levels despite having no symptoms

doi:10.1016/S0140-6736(22)02033-5 Evidence-Base Disclosure The published evidence base for Retatrutide GLP-3 consists predominantly of preclinical research animal models (often rats or mice) and in vitro cell-culture experiments