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Shuo Hu, [email protected] These authors have contributed equally to this work This article was submitted to Biomaterials, a section of the journal Frontiers in Bioengineering and Biotechnology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Of the 24 participants who qualified for sequencing at Week 96, 1 had conserved site substitution, 3 had polymorphic site substitutions, 15 had no change from baseline, and 5 were unable to be sequenced due to low level HBV DNA