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Upon confirmation of engraftment, mice were placed on doxycycline containing chow (625 ppm) to induce sgR-NAs and leukemia progression allowed to continue for 14 additional days after which mice were sacrificed using CO 2 asphyxiation, and bone marrow, dissociated spleen and peripheral blood were collected

Folic acid is not a substitute for vitamin B12 although it may improve vitamin B12 deficient megaloblastic anemia

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There is also a risk of an allergic reaction to the materials

Thrombosis and Vascular Inflammation in Diabetes: Mechanisms and Potential Therapeutic Targets