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However, the most vital of these is the KX modifier

DOI: 10.3389/fphar.2021.627533

& Meier, R

Biochim Biophys Acta 1830(5):32893303

This dual action activates regenerative TGF- signaling while blocking fibrotic TGF-1/Smad2/3 pathways, demonstrating context-dependent regulatory sophistication