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thus temperate species could be suitable surrogates for understudied Arctic species

High intake of UPFs may cause dysfunction of the metallothionein genes and suppression of the paraoxonase-1 gene (PON1) (151)

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191 Snail and Slug can competitively bind to the E-box sequence of the proximal promoter of E-cadherin gene with SMAD-associated protein 1 (SIP1), thereby inhibiting the expression of E-cadherin and inducing EMT in cells

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However, the discovery of functional extrinsic death receptor-mediated eryptosis and necroptosis of erythrocytes associated with the necrosome formation opens new horizons for our understanding of the possible role of caspases in mature erythrocytes, since caspase-8 might be involved in coordinating the cell fate of mature erythrocytes