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72 TNF- stimulates the pulmonary microvascular endothelial cells to promote the accumulation, adhesion and migration of the polymorphonuclear leucocytes by inducing the expression of IL-8 and upregulating endothelial adhesion molecules, causes release of lysosomal enzymes, elastase and large quantities of ROS

Other aspects of treatment vary according to the cause of liver failure (Table 3)

doi: 10.1038/ni.2556 200 BuckMDO'SullivanDPearceEL

Lifestyle modification Lifestyle modifications aimed at adjusting dietary patterns and increasing physical activity are the cornerstone of treating all forms of MAFLD

Statistical analyses All statistical analyses were performed using GraphPad Prism v.10 software

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