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This modification positively regulates PARP1 recruitment to sites of DNA damage and augments its enzymatic activity in response to oxidative stress [45] (Figure 4A)

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Furthermore, it alters the nucleic acid composition by reacting selectively with deoxyguanosine [43]

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Nucleic Acids Res 47: D419D426 Miorin L, Kehrer T, SanchezAparicio MT, Zhang K, Cohen P, Patel RS, Cupic A, Makio T, Mei M, Moreno E et al (2020) SARSCoV2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

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