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SOD2 plays a role in the mitochondrial antioxidant system and a reduction in SOD2 activity has already been associated with increased oxidative levels and cancer potential (van Remmen et al., 2003

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Furthermore, since p53/p21 pathway activation might also lead to apoptosis, we investigated the levels of Bcl2 and observed a decrease in its amount upon T-DXd treatment (Fig

For C/EBP isoform knockdown experiments, transfection of siRNAs was performed a second time, 24 h after the first transfection