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The specifics of the interactions between genetic predisposition and environmental exposures are not well understood at this time, despite the fact that a large number of researchers believe that the majority of cases are influenced by both genetic predisposition and environmental exposures

Simultaneously, angiogenesis-related factors induce macrophage polarization toward the M2 phenotype, thereby leading to the development of an immunosuppressive tumor microenvironment (TME)

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PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews

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