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Prostate cancer foundation white paper on combination therapy for metastatic hormone-sensitive prostate cancer

In our structure Cys497 hTrxR1 and Cys35 hTrx1 are 10 apart

AFPs are particularly promising because they can recognize multiple microbial targets, thus reducing the possibility of resistance development (Rautenbach et al., 2016), a topic that is discussed in more detail in the following section

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For instance, Mn 2+ physiologically supports the catalytic activity of glutamine synthetase (GS) as an essential divalent metal cofactor, while excessive Mn exposure can toxicologically impair GS expression and/or activity and disrupt the broader glutamateglutamine (GluGln) cycling network, thereby increasing the glutamate burden and the risk of excitotoxicity 144,179