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In an in vitro study of PQ-treated lung epithelial cells (MLE-12 cells), Quercetin was found to modulate the fibrotic process mediated by the TGF-1/Smad and Akt/mTOR signaling pathways, altering the expression of markers of the epithelial-mesenchymal transition (EMT) and inhibiting the onset of fibrosis, resulting in improved cell survival

Tsuda H, Sekine K, Ki F, Iigo M

In addition, M1-mAChR may play a key role in the process of inhibiting ferroptosis

[45] demonstrated that culturing TIG-1, WI-38, MRC-5, HeLa, and HepG2 cells with Pt nanozymes at concentrations up to 50 g/mL did not induce cytotoxicity, oxidative stress, or cell death

Nat Rev Immunol 11(2):119130 Capon F (2017) The genetic basis of psoriasis

238,239 Senescent macrophages in the eyes secrete proinflammatory cytokines via STAT3 signaling, aggravating retinal damage and promoting neovascularization, a hallmark of AMD