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Medical Treatments Some medical treatments are prescribed for, and can help with, severe PMS and PMDD

However, the effects are typically shorter-lived than B12 shots, with most people scheduling treatments every few weeks to maintain optimal vitamin levels

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Murine studies show no acute toxicity at doses up to 100 mg/kg, and the Nature Metabolism paper reported no adverse metabolic effects during the 11-week treatment period

One study took a group of eight elderly patients with anemia associated with kidney disease