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For UCD522, this curvilinear response is in contrast with the generally accepted paradigm that increasing YAN concentration reduces the H 2 S production during fermentation (Vos and Gray, 1979

however, this therapeutic effect is abolished following vagotomy, indicating that the gut microbiotas influence on behavior is mediated via vagal signaling (Sgritta et al., 2019)

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The theoretical basis for combining them is sound