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TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCalpha-NOX4 axis

Immunity (2012) 36(1):12031.10.1016/j.immuni.2011.11.018 71 CrowYJHaywardBEParmarRRobinsPLeitchAAliMet alMutations in the gene encoding the 3-5 DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus

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TB-4 (full-length thymosin 4, 43 aa) Moves repair cells (fibroblasts) into position and biases healing toward functional tissue rather than rope-like scarring. KPV Pre-empts the inflammation switch before it activates, so reactive skin doesnt drown the rebuilding signals

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