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HMGB1 belongs to DAMPs and is one of the key elements for tumor cell immunogenicity, as it will bind to its receptor and activate the immune system once it is released outside of cell (89)

Conventional treatments are effective and fewer side effects are frequently inevitable and limit clinical utility

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Species Reactivity Human, Mouse Validated Applications WB, IF-Cell, FC, IHC-P Target Molecular Weight Predicted band size: 22 kDa Positive Control HEK-293 cell lysate, HepG2 cell lysate, SH-SY5Y cell lysate, HT-29 cell lysate, human liver tissue lysate, human kidney tissue lysate, THP-1, human liver tissue

First of all, although the blockade of a single target can achieve precise intervention, it cannot block the complex network of pathological processes