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Kaas et al., 2010

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The therapeutic activation of this pathway with compounds such as dimethyl fumarate, tert-butylhydroquinone and sulforaphane can inhibit ferroptosis by upregulating the expression of downstream antioxidant genes (57)

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Epigenetic reprogramming of metabolic pathways a root cause of cancer etiology and progression Epigenetic modulators act during tumor progression to impose restrictions on the expression of tumor suppressor genes while inducing the expression of oncogenes