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We also demonstrate that APR-246 modulates xCT expression in both a p53-dependent and -independent manner

10.1016/j.tips.2023.07.007 136 SainiK

used machine learning to identify what they refer to as a neurobiological craving signature, which involves activation of the ventromedial prefrontal and cingulate cortices, ventral striatum, temporal/parietal association areas, mediodorsal thalamus and cerebellum [75]

The bioreactor maintained 100% conversion over 41 batches, producing 95 g of nicotinic acid at 90% yield

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