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Regardless of the explanation, these data suggest that other more frequent administration schedules of pemetrexed, such as bi-weekly regimens, should be explored to optimise its antiproliferative effects

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In PARP-1 knockout mice, YAP activity and the expression of cell cycle-related proteins in liver tissue are suppressed, resulting in reduced hepatocyte proliferation and impaired liver repair during liver regeneration (30)

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