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J Biol Chem (1991) 266(17):107314

The cadmium in nicotine lowers the effectiveness of antioxidants like vitamins C and E, and glutathione, and reduces hormone production, including serotonin and melatonin

Common Signs Your Glutathione May Be Low While only a health professional can determine your specific levels, many people look for signs that their body might need more antioxidant support