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Animal models remain essential for validating the efficacy, safety, and immunogenicity of nanoparticle-based vaccines

10.1080/10408398.2019.1570913 77 HouY.-C.ChuC.-C.KoT.-L.YehC.-L.YehS.-L

68 HP 125 FRAG 176-191 HGH C-Terminal Fragment Lipolytic Only ALIASES Frag 176-191, HGH Fragment 176-191, AOD-9604 parent fragment, lipolytic HGH C-terminus CLASS Synthetic peptide HGH C-terminal lipolytic fragment FORMULA C78H125N23O23S2 SEQUENCE Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (residues 176-191 of human GH) HALF-LIFE ~30 minutes (rapid plasma clearance) ROUTES Subcutaneous (research) MECHANISM OF ACTION 16-amino-acid C-terminal fragment of human growth hormone (residues 176-191), also known as AOD-9604 in its modified form

n = 37 independent experiments

Ravandi F, Pierce S, Garcia-Manero G, Kadia T, Jabbour E, Borthakur G , DiNardo CD, Daver N, Short NJ, Alvarado Y, Cortes J, Kim C, Kelsh M, Katz A, Williams R, Yang Z, Mehta B, Kantarjian H

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