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One of the main mechanisms for this is the B12-dependent regeneration of the myelin sheaths, a fat-rich protective layer around the nerve cords, which maintains nerve conductivity on the one hand, and protects the nerves from neurotoxic substances, radicals and toxins, on the other

Methylation, inflammation, and skin appearance B12 drives the methylation cycle, which among other functions helps regulate homocysteine an amino acid linked to inflammation and vascular stress when it accumulates

It highlights emerging therapies such as enzyme replacement therapies, gene therapy, and pharmacological chaperones that aim to correct the underlying metabolic imbalances in HCU

2021 (PMID 34827486), published in Brain Sciences by a Chinese research group with no tie to the WSU lab, tested Dihexa in APP/PS1 transgenic mice a standard Alzheimer's disease model

Christopher Traenka: Nothing to disclose