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To understand the catalytic mechanism of the ADP-ribosylhydrolase (ARH) activity of MavL, we screened its active truncation mutants and succeeded in solving the structure of the MavL 40-404 -ADPR complex at a resolution of 2.38 , which revealed that several pairs of hydrogen bonds and a - stacking interaction provided by surrounding amino acids or water molecules are involved in interactions between MavL and ADPR (Supplementary Fig

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Therefore, based on the characteristic of membrane location and strong protection against ferroptosis, FSP1 is a potential candidate for ferroptosis-targeted drug discovery

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Abcam, Cambridge, MA, USA) and mouse monoclonal anti-6 His antibody (#66005-1-Ig, Proteintech, Hubei, China)were used to label the S-glutathionylated and 6 His-tagged proteins, respectively

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