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Although antioxidant defense mechanisms [glutathione peroxidase (GPx), peroxiredoxin (Prx), and catalase (Cat)] work to neutralize ROS, their capacity is often overwhelmed in chronic pain states

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The Sun 2021 study used the APP/PS1 transgenic mouse model of Alzheimers disease, with intragastric administration of Dihexa at 1.44 mg/kg or 2.88 mg/kg once daily for three months (six to nine months of age in the APP/PS1 cohort)