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TFR1 mediates iron homeostasis by regulating iron uptake through the endocytosis of iron-loaded TF

A total of 69 consecutive PD patients and 32 HC were enrolled in the study

Side Effects: Sedation Parkinsonism symptoms QT prolongation (may be significant if taking with drugs inhibiting CYP3A4/5 or 2D6) Pharmacokinetics: undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 deuterated active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug twice a day dosing effect half life 9.4 hours (Schneider et al, 2021) HT: Resistant Hypertension

After a 12-week run-in period, patients were randomized to either continue DPA (N=27) or mg-to-mg change to trientine tetrahydrochloride (TETA4;N=26) for 24 weeks study period + 24 weeks extension

Annals of Clinical & Laboratory Science, 45(4), 426-432

Metabolites 13, 738