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Antibodies specific for ACTL6A (Abcam, ab3882, 1:4000), GCLC (Abcam, ab190685, 1:4000), anti-NRF2 (Cell Signaling Technology, 12721 s, 1:2000), flag-tag (Sigma, F1804, 1:5000), and GAPDH (Proteintech, 10494-1-AP, 1:5000) were purchased from the indicated companies

Mechanistically, Kla modification orchestrates TAM-dependent tumor progression through tissue-specific pathways: in gastric cancer, H3K18la induces sustained VCAM1 expression to activate AKT/mTOR/CXCL1 signaling and facilitate M2 macrophage recruitment (72)

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This notion was supported by CHX chase assays showing that SKP2 protein turnover was accelerated by SIRT7 KD, and stabilized by ectopic SIRT7 overexpression (Fig

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Atm is a redox sensor linking genome stability and carbon metabolism