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NHPN-1010 regenerated cochlear synapses following acoustic trauma, as documented by confocal microscopy of immunolabeled cochlear sensory epithelia In examining NHPN-1010induced synaptogenesis in the IHC area, presynaptic ribbons in IHCs were counted 8 wks after either NHPN-1010 or saline intervention in the 22.6 kHz and 32 kHz regions

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It is noteworthy that, compared to rats treated with their respective conventional drugs, animals that were administered with nanoparticle versions of CO or GSH, or their combination, exhibited a notable reduction in tissue KIM-1 and NGAL levels, as depicted in Fig

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