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It was previously found to be an extremely important intracellular degradation site, serving as the terminal destination during phagocytosis and autophagy 2

In vitro studies included primary mouse and human hepatocytes, Kupffer cells (KCs), hepatic stellate cells, and liver sinusoidal endothelial cells (LSECs)

Fits Into the Picture

In a longer term study (study 3), adult outpatients meeting DSM-IV criteria for PD who had responded during a 12-week open phase with venlafaxine hydrochloride extended-release capsules (75 to 225 mg per day) were randomly assigned to continue the same venlafaxine hydrochloride extended-release capsules dose (75, 150, or 225 mg) or switch to placebo for observation for relapse under double-blind conditions

(1992) determined cPHB levels in plasma of a random group of 24 normal adults and found that concentrations varied from 0.6 to 18.2 mg/l, with a mean of 3.5 mg/l