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GSK-3 also mediates the ubiquitination and degradation of Mcl-1

Brancolini, G

doi: 10.1093/annonc/mdn541 153 Sartore-BianchiAMartiniMMolinariFVeroneseSNichelattiMArtaleSet al

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Structural modifications, including pegylation and glycosylation, enhance protein stability and prolong half-life, thereby improving therapeutic efficacy [285]