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References: Anderson MF, Nilsson M, Sims NR

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In contrast, up regulation of PKC in DPN has been associated with endoplasmic reticulum stress, autophagic formation and pain (60)

Class III: K+ Channel Blockers/Openers Potassium channel blockers decrease potassium efflux out of the cell and prolong the QTc interval (4)

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This highlights the likelihood that SOD1 monomerization acts in concert with reduced copper or zinc affinity, thermal instability, disulphide reduction and local or global unfolding as the toxic cue